IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells.

IFN-γ and TNF-α synergize to inhibit CTGF expression in human lung endothelial cells.

Connective tissue growth factor (CTGF/CCN2) is an angiogenetic and profibrotic factor, acting downstream of TGF-β, involved in both airway- and vascular remodeling. While the T-helper 1 (Th1) cytokine interferon-gamma (IFN-γ) is well characterized as immune-modulatory and anti-fibrotic cytokine, the...

Full description

Bibliographic Details
Main Authors: Roderich Laug, Markus Fehrholz, Norbert Schütze, Boris W Kramer, Vera Krump-Konvalinkova, Christian P Speer, Steffen Kunzmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3447888?pdf=render

Internet

http://europepmc.org/articles/PMC3447888?pdf=render

Similar Items