Size-dependent patterns of cell proliferation and migration in freely-expanding epithelia

The coordination of cell proliferation and migration in growing tissues is crucial in development and regeneration but remains poorly understood. Here, we find that, while expanding with an edge speed independent of initial conditions, millimeter-scale epithelial monolayers exhibit internal patterns...

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Bibliographic Details
Main Authors: Matthew A Heinrich, Ricard Alert, Julienne M LaChance, Tom J Zajdel, Andrej Košmrlj, Daniel J Cohen
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/58945