Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Abstract Background Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determining region Y-box 2 (SOX2) overlapping transcript (SOX2OT), a known regul...

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Bibliographic Details
Main Authors: Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao, Yan Xing
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Journal of Neuroinflammation
Subjects:
Sepsis-associated encephalopathy
Cognitive dysfunction
Hippocampal neurogenesis
SOX2OT
SOX2
Online Access:http://link.springer.com/article/10.1186/s12974-020-01970-7

Internet

http://link.springer.com/article/10.1186/s12974-020-01970-7

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