Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity

Defucosylation of Tumor-Specific Humanized Anti-MUC1 Monoclonal Antibody Enhances NK Cell-Mediated Anti-Tumor Cell Cytotoxicity

Antibodies are commonly used in cancer immunotherapy because of their high specificity for tumor-associated antigens. The binding of antibodies can have direct effects on tumor cells but also engages natural killer (NK) cells via their Fc receptor. Mucin 1 (MUC1) is a highly glycosylated protein exp...

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Bibliographic Details
Main Authors: Ying Gong, Roel G. J. Klein Wolterink, Valeriia Gulaia, Silvie Cloosen, Femke A. I. Ehlers, Lotte Wieten, Yvo F. Graus, Gerard M. J. Bos, Wilfred T. V. Germeraad
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
antibody therapy
natural killer cells
MUC1
antibody-dependent cellular cytotoxicity
breast cancer
Online Access:https://www.mdpi.com/2072-6694/13/11/2579

Internet

https://www.mdpi.com/2072-6694/13/11/2579

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