Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes.

Alpha-interferon suppresses hepadnavirus transcription by altering epigenetic modification of cccDNA minichromosomes.

Covalently closed circular DNA (cccDNA) of hepadnaviruses exists as an episomal minichromosome in the nucleus of infected hepatocyte and serves as the transcriptional template for viral mRNA synthesis. Elimination of cccDNA is the prerequisite for either a therapeutic cure or immunological resolutio...

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Bibliographic Details
Main Authors: Fei Liu, Matthew Campagna, Yonghe Qi, Xuesen Zhao, Fang Guo, Chunxiao Xu, Sichen Li, Wenhui Li, Timothy M Block, Jinhong Chang, Ju-Tao Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3771898?pdf=render

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http://europepmc.org/articles/PMC3771898?pdf=render

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