How to Capitalize on the Retest Effect in Future Trials on Huntington's Disease.

The retest effect-improvement of performance on second exposure to a task-may impede the detection of cognitive decline in clinical trials for neurodegenerative diseases. We assessed the impact of the retest effect in Huntington's disease trials, and investigated its possible neutralization. We...

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Main Authors: Catherine Schramm, Sandrine Katsahian, Katia Youssov, Jean-François Démonet, Pierre Krystkowiak, Frédéric Supiot, Christophe Verny, Laurent Cleret de Langavant, Anne-Catherine Bachoud-Lévi, European Huntington's Disease Initiative Study Group and the Multicentre Intracerebral Grafting in Huntington's Disease Group
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4703129?pdf=render