Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 ​cells to deliver of GDNF to the brain. In vivo studies demonstrated...

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Bibliographic Details
Main Authors: Lars U. Wahlberg, Dwaine F. Emerich, Jeffrey H. Kordower, William Bell, Tracie Fradet, Giovanna Paolone
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
Encapsulation
GDNF
Neuroprotection
Neuroregeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S259025712030002X

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http://www.sciencedirect.com/science/article/pii/S259025712030002X

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