Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Deletion of SIRPα (signal regulatory protein-α) promotes phagocytic clearance of myelin debris in Wallerian degeneration, axon regeneration, and recovery from nerve injury

Abstract Background Recovery of function from traumatic nerve injury depends on the ability of severed axons to grow/regenerate back to their target tissues. This is achieved by successfully crossing the lesion site where physical impact severed axons, determined by the type of trauma, followed by s...

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Bibliographic Details
Main Authors: Gerard Elberg, Sigal Liraz-Zaltsman, Fanny Reichert, Takashi Matozaki, Michael Tal, Shlomo Rotshenker
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Journal of Neuroinflammation
Subjects:
SIRPα
Peripheral nerve
Nerve injury
Wallerian degeneration
Macrophages
Phagocytosis
Online Access:https://doi.org/10.1186/s12974-019-1679-x

Internet

https://doi.org/10.1186/s12974-019-1679-x

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