Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer’s Disease

Sex-Specific Effects of Chronic Creatine Supplementation on Hippocampal-Mediated Spatial Cognition in the 3xTg Mouse Model of Alzheimer’s Disease

The creatine (Cr) energy system has been implicated in Alzheimer’s disease (AD), including reductions in brain phosphoCr and Cr kinase, yet no studies have examined the neurobehavioral effects of Cr supplementation in AD, including the 3xTg mouse model. This studied investigated the effects of Cr su...

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Bibliographic Details
Main Authors: Wanda M. Snow, Chris Cadonic, Claudia Cortes-Perez, Aida Adlimoghaddam, Subir K. Roy Chowdhury, Ella Thomson, Adama Anozie, Michael J. Bernstein, Kathleen Gough, Paul Fernyhough, Miyoung Suh, Benedict C. Albensi
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Nutrients
Subjects:
creatine
Alzheimer’s disease
hippocampus
3xTg model
Morris water maze
nuclear factor kappa b
Online Access:https://www.mdpi.com/2072-6643/12/11/3589

Internet

https://www.mdpi.com/2072-6643/12/11/3589

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