A novel biosensor based on intestinal 3D organoids for detecting the function of BCRP

Breast cancer resistance protein (BCRP), a key drug efflux transporter, significantly affects the therapeutic efficacy of many drugs. Thus, screening specific BCRP inhibitors and distinguishing between substrates and non-substrates of BCRP are valuable in drug discovery and development. This study p...

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Bibliographic Details
Main Authors: Lei Zhang, Junfang Zhao, Chenmeizi Liang, Mingyao Liu, Feng Xu, Xin Wang
Format: Article
Language:English
Published: Taylor & Francis Group 2017-01-01
Series:Drug Delivery
Subjects:
Online Access:http://dx.doi.org/10.1080/10717544.2017.1381199