Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

Homocysteine Triggers Inflammatory Responses in Macrophages through Inhibiting CSE-H2S Signaling via DNA Hypermethylation of CSE Promoter

Hyperhomocysteinemia (HHcy) is an independent risk factor of atherosclerosis and other cardiovascular diseases. Unfortunately, Hcy-lowering strategies were found to have limited effects in reducing cardiovascular events. The underlying mechanisms remain unclear. Increasing evidence reveals a role of...

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Bibliographic Details
Main Authors: Jiao-Jiao Li, Qian Li, Hua-Ping Du, Ya-Li Wang, Shou-Jiang You, Fen Wang, Xing-Shun Xu, Jian Cheng, Yong-Jun Cao, Chun-Feng Liu, Li-Fang Hu
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:International Journal of Molecular Sciences
Subjects:
homocysteine
cystathionine γ-lyase
hydrogen sulfide
macrophage
DNA methylation
Online Access:http://www.mdpi.com/1422-0067/16/6/12560

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http://www.mdpi.com/1422-0067/16/6/12560

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