pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?

pKa modulation of the acid/base catalyst within GH32 and GH68: a role in substrate/inhibitor specificity?

Glycoside hydrolases of families 32 (GH32) and 68 (GH68) belong to clan GH-J, containing hydrolytic enzymes (sucrose/fructans as donor substrates) and fructosyltransferases (sucrose/fructans as donor and acceptor substrates). In GH32 members, some of the sugar substrates can also function as inhibit...

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Bibliographic Details
Main Authors: Shuguang Yuan, Katrien Le Roy, Tom Venken, Willem Lammens, Wim Van den Ende, Marc De Maeyer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3360783?pdf=render

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http://europepmc.org/articles/PMC3360783?pdf=render

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