MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway

MicroRNA-145 Increases the Apoptosis of Activated Hepatic Stellate Cells Induced by TRAIL through NF-κB Signaling Pathway

During the liver fibrosis recovery stage tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can effectively induce apoptosis of activated hepatic stellate cells (HSCs). Normal hepatic stellate cells are resistant to TRAIL cytotoxicity. Therefore, enhancing the sensitivity of TRAIL-induc...

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Bibliographic Details
Main Authors: Junfa Yang, Qingxue Liu, Shiyang Cao, Tao Xu, Xiaofeng Li, Dandan Zhou, Linxin Pan, Changyao Li, Cheng Huang, Xiaoming Meng, Lei Zhang, Xiao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
liver fibrosis
miR-145
hepatic stellate cells
TRAIL
apoptosis
ZEB2
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00980/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00980/full

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