Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

Silencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation

Homozygosity of loss-of-function mutations in ANGPTL3 (angiopoietin-like protein 3)-gene results in FHBL2 (familial combined hypolipidaemia, OMIM #605019) characterized by the reduction of all major plasma lipoprotein classes, which includes VLDL (very-low-density lipoprotein), LDL (low-density lip...

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Bibliographic Details
Main Authors: Anna Tikka, Jarkko Soronen, Pirkka‑Pekka Laurila, Jari Metso, Christian Ehnholm, Matti Jauhiainen
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2014-12-01
Series:Bioscience Reports
Subjects:
ANGPTL3 silencing
hypolipidaemia
insulin signalling
liver
rosiglitazone
VLDL
Online Access:http://www.bioscirep.org/bsr/034/e160/bsr034e160.htm

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http://www.bioscirep.org/bsr/034/e160/bsr034e160.htm

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