Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy

Systems Analysis of Drug-Induced Receptor Tyrosine Kinase Reprogramming Following Targeted Mono- and Combination Anti-Cancer Therapy

The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single drug therapy. Reprogramming of the RTK network...

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Bibliographic Details
Main Authors: Alexey Goltsov, Yusuf Deeni, Hilal S. Khalil, Tero Soininen, Stylianos Kyriakidis, Huizhong Hu, Simon P. Langdon, David J. Harrison, James Bown
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Cells
Subjects:
HER2
HER3
trastuzumab
pertuzumab
combination cancer therapy
signalling reprogramming
Online Access:http://www.mdpi.com/2073-4409/3/2/563

Internet

http://www.mdpi.com/2073-4409/3/2/563

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