Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts

Targeting thymidine phosphorylase inhibition in human colorectal cancer xenografts

Human thymidine phosphorylase (hTP) is overexpressed in several solid tumors and is commonly associated with aggressiveness and unfavorable prognosis. 6-(((1,3-Dihydroxypropan-2-yl)amino)methyl)-5-iodopyrimidine-2,4(1H,3H)-dione (CPBMF-223) is a noncompetitive hTP inhibitor, which has been described...

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Bibliographic Details
Main Authors: Nathalia D. de Moura Sperotto, Rodrigo Braccini Madeira Silva, Marcia Alberton Perelló, Ana Flávia Borsoi, Adilio da Silva Dadda, Candida Deves Roth, Raquel Dal Sasso Freitas, Ana Paula Duarte de Souza, Deise do Nascimento de Freitas, Jaqueline Nascimento Picada, Jayne Torres de Sousa, Débora Dreher Nabinger, Stefani Altenhofen, Carla Denise Bonan, Valnês S. Rodrigues-Junior, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Colorectal cancer
Tumor xenograft model
Pharmacokinetics
Thymidine phosphorylase inhibitor
Toxicity
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004546

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http://www.sciencedirect.com/science/article/pii/S0753332221004546

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