In Utero Exposure To Gestational Diabetes Alters DNA Methylation And Gene Expression Of CDKN2A/B In Langerhans Islets Of Rat Offspring

In Utero Exposure To Gestational Diabetes Alters DNA Methylation And Gene Expression Of CDKN2A/B In Langerhans Islets Of Rat Offspring

Objective DNA methylation, a major epigenetic reprogramming mechanism, contributes to the increased prevalence of type 2 diabetes mellitus (T2DM). Based on genome-wide association studies, polymorphisms in CDKN2A/B are associated with T2DM. Our previous studies showed that gestational diabetes mell...

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Bibliographic Details
Main Authors: Zahra Nazari, Alireza Shahryari, Soraya Ghafari, Mohammad Nabiuni, Mohammad Jafar Golalipour
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2020-07-01
Series:Cell Journal
Subjects:
dna methylation
gestational diabetes
islets of langerhans
Online Access:https://celljournal.org/journal/article/fulltext/in-utero-exposure-to-gestational-diabetes-alters-dna-methylation-and-gene-expression-of-cdkn2a-b-in-langerhans-islets-of-rat-offspring.pdf

Internet

https://celljournal.org/journal/article/fulltext/in-utero-exposure-to-gestational-diabetes-alters-dna-methylation-and-gene-expression-of-cdkn2a-b-in-langerhans-islets-of-rat-offspring.pdf

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