Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population
Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sen...
Main Authors: | , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-11-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/21/21/8306 |
id |
doaj-6979619c7bff45d593bd139a3cd548de |
---|---|
record_format |
Article |
spelling |
doaj-6979619c7bff45d593bd139a3cd548de2020-11-25T04:02:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218306830610.3390/ijms21218306Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese PopulationSho Osonoi0Hiroki Mizukami1Chieko Itabashi2Kanichiro Wada3Kazuhiro Kudoh4Akiko Igawa5Saori Ogasawara6Yasuyuki Ishibashi7Makoto Daimon8Soroku Yagihashi9Shigeyuki Nakaji10Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Gastroenterological Surgery and Pediatric Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanDepartment of Social Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, JapanNormal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sensation in a rural Japanese population. A population-based study of 894 individuals (average age 53.8 ± 0.5 years) and 55 subjects with impaired fasting glucose (IFG) were enrolled in this study. Individuals with diabetes were excluded. Relationships between pain threshold induced by intraepidermal electrical stimulation (PINT) and clinico-hematological parameters associated with OS were evaluated. Univariate linear regression analyses revealed age, BMI, HbA1c, the OS biomarker urine 8-hydroxy-2′-deoxyguanosine (8-OHdG), systolic blood pressure, and decreased Achilles tendon reflex on the PINT scores. Adjustments for age, gender, and multiple clinical measures confirmed a positive correlation between PINT scores and urine 8-OHdG (β = 0.09, <i>p</i> < 0.01). Urine 8-OHdG correlated positively with higher HbA1c levels and age in the normoglycemic population. Unlike in the normoglycemic population, both inflammation and OS were correlated with elevated PINT scores in IFG subjects. OS may be a major contributing factor to elevated PINT scores in a healthy Japanese population.https://www.mdpi.com/1422-0067/21/21/8306elevated pain thresholddiabetic polyneuropathyoxidative stress8-hydroxy-2′-deoxyguanosinenormal-high HbA1cinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sho Osonoi Hiroki Mizukami Chieko Itabashi Kanichiro Wada Kazuhiro Kudoh Akiko Igawa Saori Ogasawara Yasuyuki Ishibashi Makoto Daimon Soroku Yagihashi Shigeyuki Nakaji |
spellingShingle |
Sho Osonoi Hiroki Mizukami Chieko Itabashi Kanichiro Wada Kazuhiro Kudoh Akiko Igawa Saori Ogasawara Yasuyuki Ishibashi Makoto Daimon Soroku Yagihashi Shigeyuki Nakaji Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population International Journal of Molecular Sciences elevated pain threshold diabetic polyneuropathy oxidative stress 8-hydroxy-2′-deoxyguanosine normal-high HbA1c inflammation |
author_facet |
Sho Osonoi Hiroki Mizukami Chieko Itabashi Kanichiro Wada Kazuhiro Kudoh Akiko Igawa Saori Ogasawara Yasuyuki Ishibashi Makoto Daimon Soroku Yagihashi Shigeyuki Nakaji |
author_sort |
Sho Osonoi |
title |
Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population |
title_short |
Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population |
title_full |
Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population |
title_fullStr |
Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population |
title_full_unstemmed |
Increased Oxidative Stress Underlies Abnormal Pain Threshold in a Normoglycemic Japanese Population |
title_sort |
increased oxidative stress underlies abnormal pain threshold in a normoglycemic japanese population |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
Normal-high HbA1c levels are a risk factor for attenuated pain sensation in normoglycemic subjects. It is unclear, however, what mechanisms underlie the pathogenesis of attenuated pain sensation in such a population. We, therefore, explored the relationship between oxidative stress (OS) and pain sensation in a rural Japanese population. A population-based study of 894 individuals (average age 53.8 ± 0.5 years) and 55 subjects with impaired fasting glucose (IFG) were enrolled in this study. Individuals with diabetes were excluded. Relationships between pain threshold induced by intraepidermal electrical stimulation (PINT) and clinico-hematological parameters associated with OS were evaluated. Univariate linear regression analyses revealed age, BMI, HbA1c, the OS biomarker urine 8-hydroxy-2′-deoxyguanosine (8-OHdG), systolic blood pressure, and decreased Achilles tendon reflex on the PINT scores. Adjustments for age, gender, and multiple clinical measures confirmed a positive correlation between PINT scores and urine 8-OHdG (β = 0.09, <i>p</i> < 0.01). Urine 8-OHdG correlated positively with higher HbA1c levels and age in the normoglycemic population. Unlike in the normoglycemic population, both inflammation and OS were correlated with elevated PINT scores in IFG subjects. OS may be a major contributing factor to elevated PINT scores in a healthy Japanese population. |
topic |
elevated pain threshold diabetic polyneuropathy oxidative stress 8-hydroxy-2′-deoxyguanosine normal-high HbA1c inflammation |
url |
https://www.mdpi.com/1422-0067/21/21/8306 |
work_keys_str_mv |
AT shoosonoi increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT hirokimizukami increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT chiekoitabashi increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT kanichirowada increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT kazuhirokudoh increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT akikoigawa increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT saoriogasawara increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT yasuyukiishibashi increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT makotodaimon increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT sorokuyagihashi increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation AT shigeyukinakaji increasedoxidativestressunderliesabnormalpainthresholdinanormoglycemicjapanesepopulation |
_version_ |
1724442748956704768 |