Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial–mesenchymal transition

Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial–mesenchymal transition

Idiopathic pulmonary fibrosis (IPF) is the most common and most deadly form of interstitial lung disease. Osteopontin (OPN), a matricellular protein with proinflammatory and profibrotic properties, plays a major role in several fibrotic diseases, including IPF; OPN is highly upregulated in patients’...

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Bibliographic Details
Main Authors: Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Pulmonary fibrosis
Osteopontin
Epithelial–mesenchymal transition
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004182

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http://www.sciencedirect.com/science/article/pii/S0753332221004182

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