The Mitochondrial PHB Complex Determines Lipid Composition and Interacts With the Endoplasmic Reticulum to Regulate Ageing

The Mitochondrial PHB Complex Determines Lipid Composition and Interacts With the Endoplasmic Reticulum to Regulate Ageing

Metabolic disorders are frequently associated with physiological changes that occur during ageing. The mitochondrial prohibitin complex (PHB) is an evolutionary conserved context-dependent modulator of longevity, which has been linked to alterations in lipid metabolism but which biochemical function...

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Bibliographic Details
Main Authors: Artur B. Lourenço, María Jesús Rodríguez-Palero, Mary K. Doherty, David Cabrerizo Granados, Blanca Hernando-Rodríguez, Joaquín J. Salas, Mónica Venegas-Calerón, Phillip D. Whitfield, Marta Artal-Sanz
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Physiology
Subjects:
mitochondria
prohibitin (PHB)
insulin
ageing
lipidomics
yolk
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.696275/full

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https://www.frontiersin.org/articles/10.3389/fphys.2021.696275/full

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