Hypoxia-ischemia or excitotoxin-induced tissue plasminogen activator- dependent gelatinase activation in mice neonate brain microvessels.

Hypoxia-ischemia (HI) and excitotoxicity are validated causes of neonatal brain injuries and tissue plasminogen activator (t-PA) participates in the processes through proteolytic and receptor-mediated pathways. Brain microvascular endothelial cells from neonates in culture, contain and release more...

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Bibliographic Details
Main Authors: Priscilla L Omouendze, Vincent J Henry, Baptiste Porte, Nicolas Dupré, Peter Carmeliet, Bruno J Gonzalez, Stéphane Marret, Philippe Leroux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3735506?pdf=render