Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Apolipoprotein E and clusterin inhibit the early phase of amyloid-β aggregation in an in vitro model of cerebral amyloid angiopathy

Abstract Sporadic cerebral amyloid angiopathy (CAA) is characterized by cerebrovascular amyloid-β (Aβ) deposition, which leads to lobar hemorrhage and dementia. Biological molecules affecting the development of CAA have not been fully characterized. In this study, we performed proteome analysis of b...

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Bibliographic Details
Main Authors: Yoshinori Endo, Kazuhiro Hasegawa, Ryo Nomura, Hidetaka Arishima, Ken-ichiro Kikuta, Taro Yamashita, Yasuteru Inoue, Mitsuharu Ueda, Yukio Ando, Mark R. Wilson, Tadanori Hamano, Yasunari Nakamoto, Hironobu Naiki
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Acta Neuropathologica Communications
Subjects:
Cerebral amyloid angiopathy
Amyloid-β
Proteome analysis
Apolipoprotein E
Clusterin
Intramural periarterial drainage
Online Access:http://link.springer.com/article/10.1186/s40478-019-0662-1

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http://link.springer.com/article/10.1186/s40478-019-0662-1

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