Insulin Enhances Migration and Invasion in Prostate Cancer Cells by Up-Regulation of FOXC2

Insulin Enhances Migration and Invasion in Prostate Cancer Cells by Up-Regulation of FOXC2

Androgen deprivation therapy (ADT) is the standard treatment for advanced prostate cancer (PCa), yet many patients relapse with lethal metastatic disease. With this loss of androgens, increased cell plasticity has been observed as an adaptive response to ADT. This includes gain of invasive and migra...

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Bibliographic Details
Main Authors: Phoebe L. Sarkar, Wendy Lee, Elizabeth D. Williams, Amy A. Lubik, Nataly Stylianou, Ali Shokoohmand, Melanie L. Lehman, Brett G. Hollier, Jennifer H. Gunter, Colleen C. Nelson
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Endocrinology
Subjects:
hyperinsulinemia
prostate cancer
androgen deprivation
invasion
epithelial to mesenchymal transition (EMT)
FOXC2
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2019.00481/full

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https://www.frontiersin.org/article/10.3389/fendo.2019.00481/full

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