Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers

Increased Mortality in SDHB but Not in SDHD Pathogenic Variant Carriers

Germline mutations in succinate dehydrogenase subunit B and D (SDHB and SDHD) are predisposed to hereditary paraganglioma (PGL) and pheochromocytoma (PHEO). The phenotype of pathogenic variants varies according to the causative gene. In this retrospective study, we estimate the mortality of a nation...

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Bibliographic Details
Main Authors: Johannes A. Rijken, Leonie T. van Hulsteijn, Olaf M. Dekkers, Nicolasine D. Niemeijer, C. René Leemans, Karin Eijkelenkamp, Anouk N.A. van der Horst-Schrivers, Michiel N. Kerstens, Anouk van Berkel, Henri J.L.M. Timmers, Henricus P.M. Kunst, Peter H.L.T. Bisschop, Koen M.A. Dreijerink, Marieke F. van Dooren, Frederik J. Hes, Jeroen C. Jansen, Eleonora P.M. Corssmit, Erik F. Hensen
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Cancers
Subjects:
SDHB
SDHD
mortality
paraganglioma
pheochromocytoma
Online Access:http://www.mdpi.com/2072-6694/11/1/103

Internet

http://www.mdpi.com/2072-6694/11/1/103

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