Practical Use of Regularization in Individualizing a Mathematical Model of Cardiovascular Hemodynamics Using Scarce Data

Individualizing physiological models to a patient can enable patient-specific monitoring and treatment in critical care environments. However, this task often presents a unique “practical identifiability” challenge due to the conflict between model complexity and data scarcity. Regularization provid...

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Bibliographic Details
Main Authors: Ali Tivay, Xin Jin, Alex Kai-Yuan Lo, Christopher G. Scully, Jin-Oh Hahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00452/full