In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett’s sequence

In-depth characterization of the Wnt-signaling/β-catenin pathway in an in vitro model of Barrett’s sequence

Abstract Background An altered Wnt-signaling activation has been reported during Barrett’s esophagus progression, but with rarely detected mutations in APC and β-catenin (CTNNB1) genes. Methods In this study, a robust in-depth expression pattern analysis of frizzled receptors, co-receptors, the Wnt-...

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Bibliographic Details
Main Authors: Katharina Götzel, Olga Chemnitzer, Luisa Maurer, Arne Dietrich, Uwe Eichfeld, Orestis Lyros, Yusef Moulla, Stefan Niebisch, Matthias Mehdorn, Boris Jansen-Winkeln, Michael Vieth, Albrecht Hoffmeister, Ines Gockel, René Thieme
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Gastroenterology
Subjects:
Barrett’s esophagus
Esophageal adenocarcinoma
Wnt-signaling
Frizzled receptors
Wnt3a
Online Access:http://link.springer.com/article/10.1186/s12876-019-0957-5

Internet

http://link.springer.com/article/10.1186/s12876-019-0957-5

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