Exploring the complexity of the HIV-1 fitness landscape.

Although fitness landscapes are central to evolutionary theory, so far no biologically realistic examples for large-scale fitness landscapes have been described. Most currently available biological examples are restricted to very few loci or alleles and therefore do not capture the high dimensionali...

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Bibliographic Details
Main Authors: Roger D Kouyos, Gabriel E Leventhal, Trevor Hinkley, Mojgan Haddad, Jeannette M Whitcomb, Christos J Petropoulos, Sebastian Bonhoeffer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3297571?pdf=render