Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases

Interleukin (IL)-36 is a member of the IL-1 superfamily and includes three agonists (IL-36α, IL-36β, and IL-36γ) and an antagonist (IL-36Ra). IL-36 agonists bind to heterodimeric receptor complexes. Then, the heterotrimer complexes signal via intracellular functional domains, binding to downstream s...

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Bibliographic Details
Main Authors: Zhi-Chao Yuan, Wang-Dong Xu, Xiao-Yan Liu, Xing-You Liu, An-Fang Huang, Lin-Chong Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Immunology
Subjects:
IL-36
autoimmunity
immune cell
inflammation
cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02532/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02532/full

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