L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways

L-3-n-Butylphthalide Protects HSPB8 K141N Mutation-Induced Oxidative Stress by Modulating the Mitochondrial Apoptotic and Nrf2 Pathways

Charcot–Marie–Tooth disease (CMT), also known as hereditary motor and sensory neuropathy, is the most common inherited peripheral nerve disorder. Missense mutations, such as K141N, in the small heat shock protein HSPB8 are known to cause distal hereditary motor neuropathy 2A (dHMN2A) or Charcot-Mari...

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Bibliographic Details
Main Authors: Xiao-Dong Yang, Zhi-Dong Cen, Hai-Peng Cheng, Kai Shi, Jie Bai, Fei Xie, Hong-Wei Wu, Bei-Bei Li, Wei Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Neuroscience
Subjects:
small heat shock protein HSPB8
Charcot-Marie-Tooth disease
mitochondrial dysfunction
oxidative stress
L-3-n-butylphthalide
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00402/full

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http://journal.frontiersin.org/article/10.3389/fnins.2017.00402/full

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