A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer

A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer

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Summary: Tumor heterogeneity and cisplatin resistance are major causes of tumor relapse and poor survival. Here, we show that in lung cancer, interaction between paxillin (PXN) and integrin β4 (ITGB4), components of the focal adhesion (FA) complex, contributes to cisplatin resistance. Knocking down...

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Bibliographic Details
Main Authors: Atish Mohanty, Arin Nam, Alex Pozhitkov, Lu Yang, Saumya Srivastava, Anusha Nathan, Xiwei Wu, Isa Mambetsariev, Michael Nelson, A.R. Subbalakshmi, Linlin Guo, Mohd W. Nasser, Surinder K. Batra, John Orban, Mohit Kumar Jolly, Erminia Massarelli, Prakash Kulkarni, Ravi Salgia
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:iScience
Subjects:
Cell Biology
Mathematical Biosciences
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422030688X

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http://www.sciencedirect.com/science/article/pii/S258900422030688X

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