Inhibition of sterol biosynthesis in animal cells by 14 alpha-hydroxymethyl sterols.

The chemical syntheses of a number of 14 alpha-hydroxymethyl sterols and 14 alpha -hydroxymethyl-15 alpha-hydroxysterols and their derivatives have been pursued to permit evaluation of their activity in the inhibition of sterol biosynthesis in animal cells in culture. Described herein are chemical s...

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Bibliographic Details
Main Authors: G J Schroepfer, Jr, E J Parish, R A Pascal, Jr, A A Kandutsch
Format: Article
Language:English
Published: Elsevier 1980-07-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520422278