Interactions of IgG1 CH2 and CH3 domains with FcRn

Interactions of IgG1 CH2 and CH3 domains with FcRn

Antibody fragments are emerging as promising biopharmaceuticals because of their relatively small size and other unique properties. However, when compared to full-size antibodies, most of the current antibody fragments of VH or VL display greatly reduced half-lives. A promising approach to overcome...

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Bibliographic Details
Main Authors: Tianlei eYing, Tina W Ju, Yanping eWang, Ponraj ePrabakaran, Dimiter S Dimitrov
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Immunology
Subjects:
antibody fragments
FcRn
CH2 domain
CH3 domain
small size
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00146/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00146/full

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