Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

Iodine atoms: a new molecular feature for the design of potent transthyretin fibrillogenesis inhibitors.

The thyroid hormone and retinol transporter protein known as transthyretin (TTR) is in the origin of one of the 20 or so known amyloid diseases. TTR self assembles as a homotetramer leaving a central hydrophobic channel with two symmetrical binding sites. The aggregation pathway of TTR into amiloid...

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Bibliographic Details
Main Authors: Teresa Mairal, Joan Nieto, Marta Pinto, Maria Rosário Almeida, Luis Gales, Alfredo Ballesteros, José Barluenga, Juan J Pérez, Jesús T Vázquez, Nuria B Centeno, Maria Joao Saraiva, Ana M Damas, Antoni Planas, Gemma Arsequell, Gregorio Valencia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2607018?pdf=render

Internet

http://europepmc.org/articles/PMC2607018?pdf=render

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