Immuno-stimulation by OX40 ligand transgenic Ewing sarcoma cells

Immuno-stimulation by OX40 ligand transgenic Ewing sarcoma cells

Interleukin-2 (IL-2) transgenic Ewing sarcoma cells can induce tumor specific T and NK cell responses and reduce tumor growth in vivo and in vitro. Nevertheless, the efficiency of this stimulation is not high enough to inhibit tumor growth completely. In addition to recognition of the cognate antige...

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Bibliographic Details
Main Authors: Dajana eReuter, Martin Sebastian Staege, Caspar David Kühnöl, Juergen eFoell
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Oncology
Subjects:
Immunotherapy
Ewing sarcoma
Co-stimulation
OX40/OX40L system
tumor necrosis factor (receptor) superfamily
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00242/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00242/full

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