Role of MHC-I Expression on Spinal Motoneuron Survival and Glial Reactions Following Ventral Root Crush in Mice

Role of MHC-I Expression on Spinal Motoneuron Survival and Glial Reactions Following Ventral Root Crush in Mice

Lesions to the CNS/PNS interface are especially severe, leading to elevated neuronal degeneration. In the present work, we establish the ventral root crush model for mice, and demonstrate the potential of such an approach, by analyzing injury evoked motoneuron loss, changes of synaptic coverage and...

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Bibliographic Details
Main Authors: Luciana Politti Cartarozzi, Matheus Perez, Frank Kirchhoff, Alexandre Leite Rodrigues de Oliveira
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Cells
Subjects:
astrogliosis
PNS/CNS interface
microglial reaction
synaptic covering
β2m knockout mice
Online Access:https://www.mdpi.com/2073-4409/8/5/483

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https://www.mdpi.com/2073-4409/8/5/483

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