Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.

Extracellular vesicles released from the filarial parasite Brugia malayi downregulate the host mTOR pathway.

We have previously shown that the microfilarial (mf) stage of Brugia malayi can inhibit the mammalian target of rapamycin (mTOR; a conserved serine/threonine kinase critical for immune regulation and cellular growth) in human dendritic cells (DC) and we have proposed that this mTOR inhibition is ass...

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Bibliographic Details
Main Authors: Alessandra Ricciardi, Sasisekhar Bennuru, Sameha Tariq, Sukhbir Kaur, Weiwei Wu, Abdel G Elkahloun, Anush Arakelyan, Jahangheer Shaik, David W Dorward, Thomas B Nutman, Roshanak Tolouei Semnani
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0008884

Internet

https://doi.org/10.1371/journal.pntd.0008884

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