Critical role for Piccolo in synaptic vesicle retrieval

Critical role for Piccolo in synaptic vesicle retrieval

Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and thus may contribute to neuronal loss. Our analysi...

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Bibliographic Details
Main Authors: Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F Kent Hamra, Christian Rosenmund, Craig Curtis Garner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-05-01
Series:eLife
Subjects:
synaptic vesicles
early endosomes
recycling
Rab5
Piccolo
Online Access:https://elifesciences.org/articles/46629

Internet

https://elifesciences.org/articles/46629

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