Ribosome Evolution and Structural Capacitance

In addition to the canonical loss-of-function mutations, mutations in proteins may additionally result in gain-of-function through the binary activation of cryptic “structural capacitance elements.” Our previous bioinformatic analysis allowed us to propose a new mechanism of protein evolution – stru...

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Bibliographic Details
Main Authors: Ashley M. Buckle, Malcolm Buckle
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00123/full