The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23.

The Attenuated Brucella abortus Strain 19 Invades, Persists in, and Activates Human Dendritic Cells, and Induces the Secretion of IL-12p70 but Not IL-23.

Bacterial vectors have been proposed as novel vaccine strategies to induce strong cellular immunity. Attenuated strains of Brucella abortus comprise promising vector candidates since they have the potential to induce strong CD4(+) and CD8(+) T-cell mediated immune responses in the absence of excessi...

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Bibliographic Details
Main Authors: Mario Weinhold, Martin Eisenblätter, Edith Jasny, Michael Fehlings, Antje Finke, Hermine Gayum, Ursula Rüschendorf, Pablo Renner Viveros, Verena Moos, Kristina Allers, Thomas Schneider, Ulrich E Schaible, Ralf R Schumann, Martin E Mielke, Ralf Ignatius
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3689767?pdf=render

Internet

http://europepmc.org/articles/PMC3689767?pdf=render

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