Ionic Liquid-Promoted Synthesis of Novel Chromone-Pyrimidine Coupled Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study and Toxicity Study

Ionic Liquid-Promoted Synthesis of Novel Chromone-Pyrimidine Coupled Derivatives, Antimicrobial Analysis, Enzyme Assay, Docking Study and Toxicity Study

Herein, we report an environmentally friendly, rapid, and convenient ionic liquid ([Et3NH][HSO4])-promoted facile synthesis of ethyl 4-(6-substituted-4-oxo-4H-chromen-3-yl)-6-methyl-2-thioxo/oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate derivatives 4(a–f) and 4-(6-substituted-4-oxo-4H-chromen-3-yl)...

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Bibliographic Details
Main Authors: Shailee V. Tiwari, Julio A. Seijas, Maria Pilar Vazquez-Tato, Aniket P. Sarkate, Kshipra S. Karnik, Anna Pratima G. Nikalje
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
ionic liquid
antifungal activity
antibacterial activity
molecular docking
cytotoxicity
in vivo acute oral toxicity
Online Access:http://www.mdpi.com/1420-3049/23/2/440

Internet

http://www.mdpi.com/1420-3049/23/2/440

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