Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Activation of Nrf2/HO-1 Pathway and Human Atherosclerotic Plaque Vulnerability: An In Vitro and In Vivo Study

Reactive oxygen species (ROS) induce nuclear factor erythroid 2–related factor 2 (Nrf2) activation as an adaptive defense mechanism, determining the synthesis of antioxidant molecules, including heme-oxygenase-1 (HO-1). HO-1 protects cells against oxidative injury, degrading free heme and...

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Bibliographic Details
Main Authors: Susanna Fiorelli, Benedetta Porro, Nicola Cosentino, Alessandro Di Minno, Chiara Maria Manega, Franco Fabbiocchi, Giampaolo Niccoli, Francesco Fracassi, Simone Barbieri, Giancarlo Marenzi, Filippo Crea, Viviana Cavalca, Elena Tremoli, Sonia Eligini
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cells
Subjects:
oxidative stress
nuclear factor erythroid 2–related factor 2
heme-oxygenase-1
macrophages
plaque vulnerability
optical coherence tomography
Online Access:https://www.mdpi.com/2073-4409/8/4/356

Internet

https://www.mdpi.com/2073-4409/8/4/356

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