Epigallocathechin-O-3-Gallate Inhibits Trypanothione Reductase of Leishmania infantum, Causing Alterations in Redox Balance and Leading to Parasite Death

Epigallocathechin-O-3-Gallate Inhibits Trypanothione Reductase of Leishmania infantum, Causing Alterations in Redox Balance and Leading to Parasite Death

Leishmania infantum is a protozoan parasite that causes a vector borne infectious disease in humans known as visceral leishmaniasis (VL). This pathology, also caused by L. donovani, presently impacts the health of 500,000 people worldwide, and is treated with outdated anti-parasitic drugs that suffe...

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Bibliographic Details
Main Authors: Job D. F. Inacio, Myslene S. Fonseca, Gabriel Limaverde-Sousa, Ana M. Tomas, Helena Castro, Elmo E. Almeida-Amaral
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
EGCG
Leishmania infantum
mechanism of action
trypanothione reductase
competitive inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.640561/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.640561/full

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