hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers.

hSulf-1 gene exhibits anticancer efficacy through negatively regulating VEGFR-2 signaling in human cancers.

BACKGROUND: Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell proliferation. But hSulf-1 function is more co...

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Bibliographic Details
Main Authors: Weidan Ji, Jiahe Yang, Duanming Wang, Lu Cao, Weifeng Tan, Haihua Qian, Bin Sun, Qijun Qian, Zhengfeng Yin, Mengchao Wu, Changqing Su
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3154391?pdf=render

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http://europepmc.org/articles/PMC3154391?pdf=render

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