A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

A Danshensu-Tetramethylpyrazine Conjugate DT-010 Overcomes Multidrug Resistance in Human Breast Cancer

Background: We previously demonstrated that a Danshensu-Tetramethylpyrazine conjugate DT-010 enhanced anticancer effect of doxorubicin (Dox) in Dox-sensitive human breast cancer cells, and protected against Dox-induced cardiotoxicity. This work was designed to see whether DT-010 overcomes Dox resist...

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Bibliographic Details
Main Authors: Xinhua Zhou, Anqi Wang, Liang Wang, Jianhua Yin, Li Wang, Lijun Di, Maggie Pui-Man Hoi, Luchen Shan, Xu Wu, Yuqiang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Pharmacology
Subjects:
danshensu
tetramethylpyrazine
breast cancer
resistance
glycolysis
P-glycoprotein
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00722/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00722/full

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