Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins

Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immunotoxins have arisen as promising antitumor therapeutic...

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Bibliographic Details
Main Authors: Javier Ruiz-de-la-Herrán, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes, Javier Lacadena
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Toxins
Subjects:
immunotoxin
ribotoxin
α-sarcin
rnase t1
furin
intracellular trafficking
colorectal cancer
Online Access:https://www.mdpi.com/2072-6651/11/10/593

Internet

https://www.mdpi.com/2072-6651/11/10/593

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