Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy

Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy

Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experienc...

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Bibliographic Details
Main Authors: Federica Logiodice, Letizia Lombardelli, Ornela Kullolli, Herman Haller, Enrico Maggi, Daniel Rukavina, Marie-Pierre Piccinni
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:International Journal of Molecular Sciences
Subjects:
Th22
Th17
pregnancy
IL-22
IL-4
IL-5
IL-17
spontaneous abortion
ectopic pregnancy
implantation
Online Access:http://www.mdpi.com/1422-0067/20/2/428

Internet

http://www.mdpi.com/1422-0067/20/2/428

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