Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experienc...
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doaj-69e1fe1758e14240942ad35b3280658a2020-11-24T21:56:36ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-01-0120242810.3390/ijms20020428ijms20020428Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of PregnancyFederica Logiodice0Letizia Lombardelli1Ornela Kullolli2Herman Haller3Enrico Maggi4Daniel Rukavina5Marie-Pierre Piccinni6Department of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, ItalyDepartment of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, ItalyDepartment of Gynecology and Obstetrics, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, ItalyDepartment of Physiology and Immunology, Medical Faculty, University of Rijeka, 51000 Rijeka, CroatiaDepartment of Experimental and Clinical Medicine and DENOTHE Excellence Center, University of Florence, 50134 Florence, ItalyTrophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experiencing successful pregnancy and those experiencing unexplained recurrent abortion (URA), the levels of IL-22 produced by decidual CD4+ T cells are higher than those of peripheral blood T cells. We found a correlation of IL-22 and IL-4 produced by decidual CD4+ T cells in those experiencing successful pregnancy, not in those experiencing URA. The correlation of IL-22 and IL-4 was also found in the serum of successful pregnancy. A prevalence of CD4+ T cells producing IL-22 and IL-4 (Th17/Th2/IL-22+, Th17/Th0/IL-22+, Th17/Th2/IL-22+, and Th0/IL-22+ cells) was observed in decidua of those experiencing successful pregnancy, whereas Th17/Th1/IL-22+ cells, which do not produce IL-4, are prevalent in those experiencing URA. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells are exclusively present at the embryo implantation site where IL-4, GATA-3, IL-17A, ROR-C, IL-22, and AHR mRNA are expressed. T-bet and IFN-γ mRNA are found away from the implantation site. There is no pathogenic role of IL-22 when IL-4 is also produced by decidual CD4+ cells. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells seem to be crucial for embryo implantation.http://www.mdpi.com/1422-0067/20/2/428Th22Th17pregnancyIL-22IL-4IL-5IL-17spontaneous abortionectopic pregnancyimplantation |
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language |
English |
format |
Article |
sources |
DOAJ |
author |
Federica Logiodice Letizia Lombardelli Ornela Kullolli Herman Haller Enrico Maggi Daniel Rukavina Marie-Pierre Piccinni |
spellingShingle |
Federica Logiodice Letizia Lombardelli Ornela Kullolli Herman Haller Enrico Maggi Daniel Rukavina Marie-Pierre Piccinni Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy International Journal of Molecular Sciences Th22 Th17 pregnancy IL-22 IL-4 IL-5 IL-17 spontaneous abortion ectopic pregnancy implantation |
author_facet |
Federica Logiodice Letizia Lombardelli Ornela Kullolli Herman Haller Enrico Maggi Daniel Rukavina Marie-Pierre Piccinni |
author_sort |
Federica Logiodice |
title |
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy |
title_short |
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy |
title_full |
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy |
title_fullStr |
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy |
title_full_unstemmed |
Decidual Interleukin-22-Producing CD4+ T Cells (Th17/Th0/IL-22+ and Th17/Th2/IL-22+, Th2/IL-22+, Th0/IL-22+), Which Also Produce IL-4, Are Involved in the Success of Pregnancy |
title_sort |
decidual interleukin-22-producing cd4+ t cells (th17/th0/il-22+ and th17/th2/il-22+, th2/il-22+, th0/il-22+), which also produce il-4, are involved in the success of pregnancy |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-01-01 |
description |
Trophoblast expressing paternal HLA-C resembles a semiallograft, and could be rejected by maternal T cells. IL-22 seems to be involved in allograft rejection and thus could be responsible for miscarriages. We examined the role of decidual IL-22-producing CD4+ T on human pregnancy. In those experiencing successful pregnancy and those experiencing unexplained recurrent abortion (URA), the levels of IL-22 produced by decidual CD4+ T cells are higher than those of peripheral blood T cells. We found a correlation of IL-22 and IL-4 produced by decidual CD4+ T cells in those experiencing successful pregnancy, not in those experiencing URA. The correlation of IL-22 and IL-4 was also found in the serum of successful pregnancy. A prevalence of CD4+ T cells producing IL-22 and IL-4 (Th17/Th2/IL-22+, Th17/Th0/IL-22+, Th17/Th2/IL-22+, and Th0/IL-22+ cells) was observed in decidua of those experiencing successful pregnancy, whereas Th17/Th1/IL-22+ cells, which do not produce IL-4, are prevalent in those experiencing URA. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells are exclusively present at the embryo implantation site where IL-4, GATA-3, IL-17A, ROR-C, IL-22, and AHR mRNA are expressed. T-bet and IFN-γ mRNA are found away from the implantation site. There is no pathogenic role of IL-22 when IL-4 is also produced by decidual CD4+ cells. Th17/Th2/IL-22+ and Th17/Th0/IL-22+ cells seem to be crucial for embryo implantation. |
topic |
Th22 Th17 pregnancy IL-22 IL-4 IL-5 IL-17 spontaneous abortion ectopic pregnancy implantation |
url |
http://www.mdpi.com/1422-0067/20/2/428 |
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