Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse events. Here, the influence of probenecid on...

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Bibliographic Details
Main Authors: Koen G. A. M. Hussaarts, Leni van Doorn, Karel Eechoute, Jeffrey Damman, Qiang Fu, Nadia van Doorn, Eric D. Eisenmann, Alice A. Gibson, Esther Oomen-de Hoop, Peter de Bruijn, Sharyn D. Baker, Stijn L. W. Koolen, Teun van Gelder, Roelof W. F. van Leeuwen, Ron H. J. Mathijssen, Alex Sparreboom, Sander Bins
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Pharmaceutics
Subjects:
sorafenib
probenecid
hand-foot skin reaction (HFSR)
pharmacokinetics
OAT6
Online Access:https://www.mdpi.com/1999-4923/12/9/788

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https://www.mdpi.com/1999-4923/12/9/788

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