Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Exosomes Secreted From Bone Marrow Mesenchymal Stem Cells Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Pyroptosis in PC12 Cells by Promoting AMPK-Dependent Autophagic Flux

Background: Cerebral ischemia–reperfusion (I/R) injury can lead to severe dysfunction, and its treatment is difficult. It is reported that nucleotide-binding domain and leucine-rich repeat family protein 3 (NLRP3) inflammasome-mediated cell pyroptosis is an important part of cerebral I/R injury and...

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Bibliographic Details
Main Authors: Qing Zeng, Yuqing Zhou, Donghui Liang, He He, Xiaoli Liu, Rui Zhu, Meimei Zhang, Xun Luo, Yao Wang, Guozhi Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
autophagy
exosomes secreted from bone marrow mesenchymal stem cells
cerebral ischemia/reperfusion
pyroptosis
nucleotide-binding domain leucine-rich repeats family protein 3
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00182/full

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https://www.frontiersin.org/article/10.3389/fncel.2020.00182/full

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