Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition

Chronic Intermittent Hypoxia-Induced Vascular Dysfunction in Rats is Reverted by N-Acetylcysteine Supplementation and Arginase Inhibition

Chronic intermittent hypoxia (CIH), the main attribute of obstructive sleep apnea (OSA), produces oxidative stress, endothelial dysfunction, and hypertension. Nitric oxide (NO) plays a critical role in controlling the vasomotor tone. The NO level depends on the L-arginine level, which can be reduced...

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Bibliographic Details
Main Authors: Bernardo J. Krause, Paola Casanello, Ana C. Dias, Paulina Arias, Victoria Velarde, German A. Arenas, Marcelo D. Preite, Rodrigo Iturriaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Physiology
Subjects:
arginase
chronic intermittent hypoxia
endothelial dysfunction
nitric oxide
oxidative stress
vascular reactivity
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.00901/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.00901/full

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